The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme

Deregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynthesis pathway enzymes SMOX and PAOX, as well as th...

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Detalles Bibliográficos
Autores principales: Urban-Wójciuk, Zuzanna, Graham, Amy, Barker, Karen, Kwok, Colin, Sbirkov, Yordan, Howell, Louise, Campbell, James, Woster, Patrick M., Poon, Evon, Petrie, Kevin, Chesler, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293756/
https://www.ncbi.nlm.nih.gov/pubmed/34522028
http://dx.doi.org/10.1038/s41417-021-00386-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293756/
https://www.ncbi.nlm.nih.gov/pubmed/34522028
http://dx.doi.org/10.1038/s41417-021-00386-6

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