A transthyretin monomer intermediate undergoes local unfolding and transient interaction with oligomers in a kinetically concerted aggregation pathway

Transthyretin (TTR) amyloidosis is associated with tissue deposition of TTR aggregates. TTR aggregation is initiated by dissociation of the native tetramer to form a monomeric intermediate, which locally unfolds and assembles into soluble oligomers and higher-order aggregates. However, a detailed me...

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Detalles Bibliográficos
Autores principales: Sun, Xun, Ferguson, James A., Dyson, H. Jane, Wright, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293765/
https://www.ncbi.nlm.nih.gov/pubmed/35724960
http://dx.doi.org/10.1016/j.jbc.2022.102162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293765/
https://www.ncbi.nlm.nih.gov/pubmed/35724960
http://dx.doi.org/10.1016/j.jbc.2022.102162

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