Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis

OBJECTIVE: Inclusion body myositis (IBM) has an unclear molecular etiology exhibiting both characteristic inflammatory T-cell activity and rimmed-vacuolar degeneration of muscle fibers. Using in-depth gene expression and splicing studies, we aimed at understanding the different components of the mol...

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Detalles Bibliográficos
Autores principales: Johari, Mridul, Vihola, Anna, Palmio, Johanna, Jokela, Manu, Jonson, Per Harald, Sarparanta, Jaakko, Huovinen, Sanna, Savarese, Marco, Hackman, Peter, Udd, Bjarne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293871/
https://www.ncbi.nlm.nih.gov/pubmed/35237874
http://dx.doi.org/10.1007/s00415-022-11029-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293871/
https://www.ncbi.nlm.nih.gov/pubmed/35237874
http://dx.doi.org/10.1007/s00415-022-11029-7

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