JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...

Descripción completa

Detalles Bibliográficos
Autores principales: Chowdhury, Md Al Nayem, Wang, Shih-Wei, Suen, Ching-Shu, Hwang, Ming-Jing, Hsueh, Yi-An, Shieh, Sheau-Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293949/
https://www.ncbi.nlm.nih.gov/pubmed/35851582
http://dx.doi.org/10.1038/s41419-022-05077-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293949/
https://www.ncbi.nlm.nih.gov/pubmed/35851582
http://dx.doi.org/10.1038/s41419-022-05077-0

Ejemplares similares