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JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...

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Detalles Bibliográficos
Autores principales:	Chowdhury, Md Al Nayem, Wang, Shih-Wei, Suen, Ching-Shu, Hwang, Ming-Jing, Hsueh, Yi-An, Shieh, Sheau-Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293949/ https://www.ncbi.nlm.nih.gov/pubmed/35851582 http://dx.doi.org/10.1038/s41419-022-05077-0

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