Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model

Defects in ataxin-3 proteins and CAG repeat expansions in its coding gene ATXN3 cause Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph disease (MJD) polyglutamine neurodegenerative disease. The mutant proteins aggregate as inclusion bodies in cells and compete with wild-type ataxin-3, which le...

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Detalles Bibliográficos
Autores principales: Han, Xiaobo, de Dieu Habimana, Jean, Li, Amy L., Huang, Rongqi, Mukama, Omar, Deng, Weiyue, Wang, Ling, Zhang, Yuying, Wang, Wei, Deng, Sihao, Peng, Kexin, Ni, Bin, Zhang, Shusheng, Huang, Jufang, Yan, Xiao-xin, Li, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293975/
https://www.ncbi.nlm.nih.gov/pubmed/35851059
http://dx.doi.org/10.1038/s41419-022-05085-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293975/
https://www.ncbi.nlm.nih.gov/pubmed/35851059
http://dx.doi.org/10.1038/s41419-022-05085-0

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