Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs

Mutations in human proteins lead to diseases. The structure of these proteins can help understand the mechanism of such diseases and develop therapeutics against them. With improved deep learning techniques, such as RoseTTAFold and AlphaFold, we can predict the structure of proteins even in the abse...

Descripción completa

Detalles Bibliográficos
Autores principales: Sen, Neeladri, Anishchenko, Ivan, Bordin, Nicola, Sillitoe, Ian, Velankar, Sameer, Baker, David, Orengo, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Problem Solving Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294430/
https://www.ncbi.nlm.nih.gov/pubmed/35641150
http://dx.doi.org/10.1093/bib/bbac187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294430/
https://www.ncbi.nlm.nih.gov/pubmed/35641150
http://dx.doi.org/10.1093/bib/bbac187

Ejemplares similares