Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory

Ferroptosis provide new insights into designing nanomedicines for enhanced cancer therapy; however, its antitumor efficacy is relatively low, mainly due to self-protective mechanism of cancer cells, e.g., heat shock protein (HSP) overexpression. Since HSPs can be modified/inhibited by lipid peroxida...

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Detalles Bibliográficos
Autores principales: Xie, Li, Chen, Wenjie, Chen, Qifang, Jiang, Yang, Song, Erqun, Zhu, Xiaokang, Song, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294558/
https://www.ncbi.nlm.nih.gov/pubmed/35865409
http://dx.doi.org/10.1016/j.mtbio.2022.100353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294558/
https://www.ncbi.nlm.nih.gov/pubmed/35865409
http://dx.doi.org/10.1016/j.mtbio.2022.100353

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