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SUMOylation of Nuclear γ-Actin by SUMO2 supports DNA Damage Repair against Myocardial Ischemia-Reperfusion Injury

Myocardial infarction triggers oxidative DNA damage, apoptosis and adverse cardiac remodeling in the heart. Small ubiquitin-like modifier (SUMO) proteins mediate post-translational SUMOylation of the cardiac proteins in response to oxidative stress signals. Upregulation of isoform SUMO2 could attenu...

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Detalles Bibliográficos
Autores principales: Zhao, Wei, Zhang, Xiuying, Zhao, Jia, Fan, Ni, Rong, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295056/
https://www.ncbi.nlm.nih.gov/pubmed/35864967
http://dx.doi.org/10.7150/ijbs.74407