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Interleukin-7 regulates CD127 expression and promotes CD8(+) T cell activity in patients with primary cutaneous melanoma
BACKGROUND: Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8(+) T cell exhaustion. The mechanisms underlying CD8(+) T cell responses to IL-7 in melanoma remain not completely elucidated. We previously showed reduced IL-7 level...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295418/ https://www.ncbi.nlm.nih.gov/pubmed/35850640 http://dx.doi.org/10.1186/s12865-022-00509-0 |