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Interleukin-7 regulates CD127 expression and promotes CD8(+) T cell activity in patients with primary cutaneous melanoma

BACKGROUND: Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8(+) T cell exhaustion. The mechanisms underlying CD8(+) T cell responses to IL-7 in melanoma remain not completely elucidated. We previously showed reduced IL-7 level...

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Detalles Bibliográficos
Autores principales:	He, Hongxia, Qiao, Binjun, Guo, Shuping, Cui, Hongzhou, Zhang, Ziyan, Qin, Junxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295418/ https://www.ncbi.nlm.nih.gov/pubmed/35850640 http://dx.doi.org/10.1186/s12865-022-00509-0

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