Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial Dysfunction

CD8 T cell exhaustion is a hallmark of HIV-1 infection, characterized by phenotypic and functional CD8 T cell abnormalities that persist despite years of effective antiretroviral treatment (ART). More recently, the importance of cellular metabolism in shaping T cell antiviral function has emerged as...

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Detalles Bibliográficos
Autores principales: Alrubayyi, Aljawharah, Moreno-Cubero, Elia, Hameiri-Bowen, Dan, Matthews, Rebecca, Rowland-Jones, Sarah, Schurich, Anna, Peppa, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295450/
https://www.ncbi.nlm.nih.gov/pubmed/35865519
http://dx.doi.org/10.3389/fimmu.2022.908697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295450/
https://www.ncbi.nlm.nih.gov/pubmed/35865519
http://dx.doi.org/10.3389/fimmu.2022.908697

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