Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance

Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation...

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Autores principales: Pitton, Melissa, Oberhaensli, Simone, Appiah, Fiona, Pagani, Jean-Luc, Fournier, Anne, Jakob, Stephan M., Que, Yok-Ai, Cameron, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295567/
https://www.ncbi.nlm.nih.gov/pubmed/35852364
http://dx.doi.org/10.1128/aac.00621-22
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author Pitton, Melissa
Oberhaensli, Simone
Appiah, Fiona
Pagani, Jean-Luc
Fournier, Anne
Jakob, Stephan M.
Que, Yok-Ai
Cameron, David R.
author_facet Pitton, Melissa
Oberhaensli, Simone
Appiah, Fiona
Pagani, Jean-Luc
Fournier, Anne
Jakob, Stephan M.
Que, Yok-Ai
Cameron, David R.
author_sort Pitton, Melissa
collection PubMed
description Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.
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spelling pubmed-92955672022-07-20 Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance Pitton, Melissa Oberhaensli, Simone Appiah, Fiona Pagani, Jean-Luc Fournier, Anne Jakob, Stephan M. Que, Yok-Ai Cameron, David R. Antimicrob Agents Chemother Mechanisms of Resistance Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa. American Society for Microbiology 2022-07-05 /pmc/articles/PMC9295567/ /pubmed/35852364 http://dx.doi.org/10.1128/aac.00621-22 Text en Copyright © 2022 Pitton et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Pitton, Melissa
Oberhaensli, Simone
Appiah, Fiona
Pagani, Jean-Luc
Fournier, Anne
Jakob, Stephan M.
Que, Yok-Ai
Cameron, David R.
Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title_full Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title_fullStr Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title_full_unstemmed Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title_short Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
title_sort mutation to ispa produces stable small-colony variants of pseudomonas aeruginosa that have enhanced aminoglycoside resistance
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295567/
https://www.ncbi.nlm.nih.gov/pubmed/35852364
http://dx.doi.org/10.1128/aac.00621-22
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