Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells

An essential step in the infection life cycle of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the proteolytic activation of the viral spike (S) protein, which enables membrane fusion and entry into the host cell. Two distinct classes of host proteases have been implicated in t...

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Detalles Bibliográficos
Autores principales: Icho, Simoun, Rujas, Edurne, Muthuraman, Krithika, Tam, John, Liang, Huazhu, Landreth, Shelby, Liao, Mingmin, Falzarano, Darryl, Julien, Jean-Philippe, Melnyk, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295568/
https://www.ncbi.nlm.nih.gov/pubmed/35703551
http://dx.doi.org/10.1128/aac.00439-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295568/
https://www.ncbi.nlm.nih.gov/pubmed/35703551
http://dx.doi.org/10.1128/aac.00439-22

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