A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength

Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage choice, and ability to respond to small amounts of antigen. By using a muta...

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Detalles Bibliográficos
Autores principales: Bovolenta, Elena R., García-Cuesta, Eva M., Horndler, Lydia, Ponomarenko, Julia, Schamel, Wolfgang W., Mellado, Mario, Castro, Mario, Abia, David, van Santen, Hisse M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295770/
https://www.ncbi.nlm.nih.gov/pubmed/35617435
http://dx.doi.org/10.1073/pnas.2201907119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295770/
https://www.ncbi.nlm.nih.gov/pubmed/35617435
http://dx.doi.org/10.1073/pnas.2201907119

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