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A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage choice, and ability to respond to small amounts of antigen. By using a muta...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295770/ https://www.ncbi.nlm.nih.gov/pubmed/35617435 http://dx.doi.org/10.1073/pnas.2201907119 |