The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis

Aggregation of initially stably structured proteins is involved in more than 20 human amyloid diseases. Despite intense research, however, how this class of proteins assembles into amyloid fibrils remains poorly understood, principally because of the complex effects of amino acid substitutions on pr...

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Detalles Bibliográficos
Autores principales: Guthertz, N., van der Kant, R., Martinez, R. M., Xu, Y., Trinh, C., Iorga, B. I., Rousseau, F., Schymkowitz, J., Brockwell, D. J., Radford, S. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295795/
https://www.ncbi.nlm.nih.gov/pubmed/35613051
http://dx.doi.org/10.1073/pnas.2200468119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295795/
https://www.ncbi.nlm.nih.gov/pubmed/35613051
http://dx.doi.org/10.1073/pnas.2200468119

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