Cargando…

Investigation of Functional Synergism of CENPF and FOXM1 Identifies POLD1 as Downstream Target in Hepatocellular Carcinoma

BACKGROUND: Lines of evidence implicate CENPF and FOXM1 may have novel co-operative roles in driving hepatocellular carcinoma (HCC). OBJECTIVE: We investigated the clinicopathological correlation, functional characterization, molecular mechanism and translational significance of CENPF and FOXM1. MET...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Daniel Wai-Hung, Lam, Wai-Ling Macrina, Chan, Lo-Kong, Ng, Irene Oi-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295863/ https://www.ncbi.nlm.nih.gov/pubmed/35865168 http://dx.doi.org/10.3389/fmed.2022.860395

Ejemplares similares

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
por: Lin, Shih-Chieh, et al.
Publicado: (2016)

FOXM1 and CENPF are associated with a poor prognosis through promoting proliferation and migration in lung adenocarcinoma
por: Li, Peipei, et al.
Publicado: (2023)

Roles of human POLD1 and POLD3 in genome stability
por: Tumini, Emanuela, et al.
Publicado: (2016)

A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma
por: Tang, Hui, et al.
Publicado: (2022)

Frequent Amplification of CENPF, GMNN and CDK13 Genes in Hepatocellular Carcinomas
por: Kim, Hye-Eun, et al.
Publicado: (2012)

Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway
por: Lo, Regina Cheuk-Lam, et al.
Publicado: (2018)

Role of POLE and POLD1 in familial cancer
por: Mur, Pilar, et al.
Publicado: (2020)

POLE/POLD1 mutation and tumor immunotherapy
por: Ma, Xiaoting, et al.
Publicado: (2022)

miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression
por: Leong, Ka-Wai, et al.
Publicado: (2017)

Role of CCNB1, CENPF, and neutrophils in lung cancer diagnosis and prognosis
por: Tan, Feixiang, et al.
Publicado: (2023)

Upregulation of CENPF is linked to aggressive features of osteosarcoma
por: Zou, Ping-An, et al.
Publicado: (2021)

CTCF Mediates Replicative Senescence Through POLD1
por: Hou, Yuli, et al.
Publicado: (2021)

Prospects of POLD1 in Human Cancers: A Review
por: Gola, Michał, et al.
Publicado: (2023)

FOXM1 Is an Oncogenic Mediator in Ewing Sarcoma
por: Christensen, Laura, et al.
Publicado: (2013)

FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c
por: Lam, Andy K. Y., et al.
Publicado: (2013)

Deleted in Liver Cancer 1 (DLC1) Negatively Regulates Rho/ROCK/MLC Pathway in Hepatocellular Carcinoma
por: Wong, Carmen Chak-Lui, et al.
Publicado: (2008)

MRPL51 is a downstream target of FOXM1 in promoting the malignant behaviors of lung adenocarcinoma
por: Zhang, Wenqian, et al.
Publicado: (2023)

CENPF promotes the proliferation of renal cell carcinoma in vitro
por: Zhang, Ji, et al.
Publicado: (2023)

[Retracted] Upregulation of CENPF is linked to aggressive features of osteosarcoma
por: Zou, Ping-An, et al.
Publicado: (2023)

HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis
por: Chen, Er-Bao, et al.
Publicado: (2019)

Centromere Protein F (CENPF) Serves as a Potential Prognostic Biomarker and Target for Human Hepatocellular Carcinoma
por: Huang, Yugang, et al.
Publicado: (2021)

Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function
por: Chan, Lo-Kong, et al.
Publicado: (2009)

Transcription factor FoxM1 is the downstream target of c-Myc and contributes to the development of prostate cancer
por: Pan, Huafeng, et al.
Publicado: (2018)

E2F1 mediates the downregulation of POLD1 in replicative senescence
por: Gao, Shichao, et al.
Publicado: (2019)

Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular Carcinoma
por: Lyu, Xueying, et al.
Publicado: (2022)

The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes
por: Waters, Aoife M, et al.
Publicado: (2015)

Overexpression of CENPF is associated with progression and poor prognosis of lung adenocarcinoma
por: Li, Mei-Xiang, et al.
Publicado: (2021)

Elevated expression of POLD1 is associated with poor prognosis in breast cancer
por: Qin, Qinghong, et al.
Publicado: (2018)

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene
por: Bappy, Md. Nazmul Islam, et al.
Publicado: (2022)

Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1
por: Mur, Pilar, et al.
Publicado: (2023)

Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3
por: Gao, Fei, et al.
Publicado: (2015)

FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases
por: Zhang, Zhenwang, et al.
Publicado: (2023)

Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma
por: Fan, Weiqiang, et al.
Publicado: (2022)

Erratum: The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes
Publicado: (2016)

Human POLD1 modulates cell cycle progression and DNA damage repair
por: Song, Jing, et al.
Publicado: (2015)

Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1
por: Buchanan, Daniel D., et al.
Publicado: (2017)

Detection of Allelic Variants of The POLE and POLD1 Genes in Colorectal Cancer Patients
por: Pätzold, LA, et al.
Publicado: (2017)

POLE and POLD1 pathogenic variants in the proofreading domain in papillary thyroid cancer
por: Siraj, Abdul K, et al.
Publicado: (2020)

Assessment of POLE and POLD1 mutations as prognosis and immunotherapy biomarkers for stomach adenocarcinoma
por: Zhu, Mingyu, et al.
Publicado: (2022)

Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
por: Tsui, Yu-Man, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fprhp4md9si3u5gcnhflcerg6v