Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells

Self-renewal of spermatogonial stem cells is vital to lifelong production of male gametes and thus fertility. However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for spermatogonial stem cell self-renewal. Mice lacking DOT1L fai...

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Detalles Bibliográficos
Autores principales: Lin, Huijuan, Cheng, Keren, Kubota, Hiroshi, Lan, Yemin, Riedel, Simone S., Kakiuchi, Kazue, Sasaki, Kotaro, Bernt, Kathrin M., Bartolomei, Marisa S., Luo, Mengcheng, Wang, P. Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296001/
https://www.ncbi.nlm.nih.gov/pubmed/35738678
http://dx.doi.org/10.1101/gad.349550.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296001/
https://www.ncbi.nlm.nih.gov/pubmed/35738678
http://dx.doi.org/10.1101/gad.349550.122

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