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Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication

Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp. 718–736) add to this g...

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Detalles Bibliográficos
Autores principales: Ryniawec, John M., Rogers, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296006/
https://www.ncbi.nlm.nih.gov/pubmed/35835509
http://dx.doi.org/10.1101/gad.349815.122