Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication

Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp. 718–736) add to this g...

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Detalles Bibliográficos
Autores principales: Ryniawec, John M., Rogers, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296006/
https://www.ncbi.nlm.nih.gov/pubmed/35835509
http://dx.doi.org/10.1101/gad.349815.122
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author Ryniawec, John M.
Rogers, Gregory C.
author_facet Ryniawec, John M.
Rogers, Gregory C.
author_sort Ryniawec, John M.
collection PubMed
description Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp. 718–736) add to this growing list by describing a new mechanism of control that restricts Plk4 translation through competitive ribosome binding at upstream open reading frames (uORFs) in the mature Plk4 mRNA. Fascinatingly, this mechanism is especially critical in the development of primordial germ cells in mice that are transcriptionally hyperactive and thus exquisitely sensitive to Plk4 mRNA regulation.
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spelling pubmed-92960062022-12-01 Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication Ryniawec, John M. Rogers, Gregory C. Genes Dev Outlook Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp. 718–736) add to this growing list by describing a new mechanism of control that restricts Plk4 translation through competitive ribosome binding at upstream open reading frames (uORFs) in the mature Plk4 mRNA. Fascinatingly, this mechanism is especially critical in the development of primordial germ cells in mice that are transcriptionally hyperactive and thus exquisitely sensitive to Plk4 mRNA regulation. Cold Spring Harbor Laboratory Press 2022-06-01 /pmc/articles/PMC9296006/ /pubmed/35835509 http://dx.doi.org/10.1101/gad.349815.122 Text en © 2022 Ryniawec and Rogers; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Outlook
Ryniawec, John M.
Rogers, Gregory C.
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title_full Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title_fullStr Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title_full_unstemmed Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title_short Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
title_sort balancing the scales: fine-tuning polo-like kinase 4 to ensure proper centriole duplication
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296006/
https://www.ncbi.nlm.nih.gov/pubmed/35835509
http://dx.doi.org/10.1101/gad.349815.122
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