IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy

[Image: see text] Activation of the IRE-1/XBP-1s pathway supports tumor progression. Here, we report a novel prodrug, TC-D-F07, in which a thiol-reactive dinitrobenzenesulfonyl (Dns) cage was installed onto the C8 hydroxyl of the covalent IRE-1 inhibitor D-F07. The electron-withdrawing Dns group in...

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Detalles Bibliográficos
Autores principales: Shao, Andong, Xu, Qin, Kang, Chang Won, Cain, Christopher F., Lee, Avery C., Tang, Chih-Hang Anthony, Del Valle, Juan R., Hu, Chih-Chi Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296017/
https://www.ncbi.nlm.nih.gov/pubmed/35253431
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296017/
https://www.ncbi.nlm.nih.gov/pubmed/35253431
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00639

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