Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice

Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron (MN) disease characterized by protein misfolding and aggregation leading to cellular degeneration. So far neither biomarker, nor effective treatment has been found. ATP signaling and P2X4 receptors (P2X4) are upregulated in various neurodegen...

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Detalles Bibliográficos
Autores principales: Bertin, Eléonore, Martinez, Audrey, Fayoux, Anne, Carvalho, Kevin, Carracedo, Sara, Fernagut, Pierre-Olivier, Koch-Nolte, Friedrich, Blum, David, Bertrand, Sandrine S., Boué-Grabot, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296432/
https://www.ncbi.nlm.nih.gov/pubmed/35852606
http://dx.doi.org/10.1007/s00018-022-04461-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296432/
https://www.ncbi.nlm.nih.gov/pubmed/35852606
http://dx.doi.org/10.1007/s00018-022-04461-5

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