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Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

Epitranscriptomic RNA modifications can regulate fundamental biological processes, but we lack approaches to map modification sites and probe writer enzymes. Here we present a chemoproteomic strategy to characterize RNA 5-methylcytidine (m(5)C) dioxygenase enzymes in their native context based upon...

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Detalles Bibliográficos
Autores principales: Arguello, A. Emilia, Li, Ang, Sun, Xuemeng, Eggert, Tanner W., Mairhofer, Elisabeth, Kleiner, Ralph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296451/
https://www.ncbi.nlm.nih.gov/pubmed/35853884
http://dx.doi.org/10.1038/s41467-022-31876-2