N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells

Castration-resistance of prostate cancer is one of the most challenging clinical problems. In the present study, we have performed proteomics and glycomics using LNCaP model. Growth differentiation factor-15 (GDF15) level is increased in androgen receptor (AR) inhibitor-resistant cells and the inhib...

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Detalles Bibliográficos
Autores principales: Wang, Rong, Wen, Piaopiao, Yang, Ganglong, Feng, Yanyan, Mi, Yuanyuan, Wang, Xiaoying, Zhu, Shenglong, Chen, Yong Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296468/
https://www.ncbi.nlm.nih.gov/pubmed/35853851
http://dx.doi.org/10.1038/s41419-022-05090-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296468/
https://www.ncbi.nlm.nih.gov/pubmed/35853851
http://dx.doi.org/10.1038/s41419-022-05090-3

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