Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and...

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Detalles Bibliográficos
Autores principales: Cai, Zongye, Tian, Siyu, Klein, Theo, Tu, Ly, Geenen, Laurie W., Koudstaal, Thomas, van den Bosch, Annemien E., de Rijke, Yolanda B., Reiss, Irwin K. M., Boersma, Eric, van der Ley, Claude, Van Faassen, Martijn, Kema, Ido, Duncker, Dirk J., Boomars, Karin A., Tran-Lundmark, Karin, Guignabert, Christophe, Merkus, Daphne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296482/
https://www.ncbi.nlm.nih.gov/pubmed/35853948
http://dx.doi.org/10.1038/s41598-022-15039-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296482/
https://www.ncbi.nlm.nih.gov/pubmed/35853948
http://dx.doi.org/10.1038/s41598-022-15039-3

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