Cargando…

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα

Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic values, evaluate the effect of PAH therapy on KP-metabolites and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Zongye, Tian, Siyu, Klein, Theo, Tu, Ly, Geenen, Laurie W., Koudstaal, Thomas, van den Bosch, Annemien E., de Rijke, Yolanda B., Reiss, Irwin K. M., Boersma, Eric, van der Ley, Claude, Van Faassen, Martijn, Kema, Ido, Duncker, Dirk J., Boomars, Karin A., Tran-Lundmark, Karin, Guignabert, Christophe, Merkus, Daphne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296482/ https://www.ncbi.nlm.nih.gov/pubmed/35853948 http://dx.doi.org/10.1038/s41598-022-15039-3

Ejemplares similares

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension
por: Cai, Zongye, et al.
Publicado: (2020)

Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease
por: Sorgdrager, Freek J. H., et al.
Publicado: (2019)

Purinergic Dysfunction in Pulmonary Arterial Hypertension
por: Cai, Zongye, et al.
Publicado: (2020)

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD
por: Heylen, Annelies, et al.
Publicado: (2023)

The Prognostic Value of Soluble ST2 in Adults with Pulmonary Hypertension
por: Geenen, Laurie W., et al.
Publicado: (2019)

The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer’s Disease
por: Sorgdrager, FJH, et al.
Publicado: (2020)

The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review
por: van Zundert, Sofie KM, et al.
Publicado: (2022)

The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?
por: Broekhuizen, Michelle, et al.
Publicado: (2021)

The tryptophan kynurenine pathway, neopterin and IL-6 during vulvectomy and abdominal hysterectomy
por: Hol, Jaap Willem, et al.
Publicado: (2014)

In Matrix Derivatization Combined with LC-MS/MS Results in Ultrasensitive Quantification of Plasma Free Metanephrines and Catecholamines
por: van Faassen, Martijn, et al.
Publicado: (2020)

Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
por: Vinke, Paulien, et al.
Publicado: (2021)

Evidence for a Role of CCR6+ T Cells in Chronic Thromboembolic Pulmonary Hypertension
por: van Uden, Denise, et al.
Publicado: (2022)

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle
por: Stam, Kelly, et al.
Publicado: (2019)

Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: An Immunological Perspective
por: Koudstaal, Thomas, et al.
Publicado: (2020)

Transition from post‐capillary pulmonary hypertension to combined pre‐ and post‐capillary pulmonary hypertension in swine: a key role for endothelin
por: van Duin, Richard W. B., et al.
Publicado: (2018)

Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum
por: Janssens, Jana, et al.
Publicado: (2020)

IL-6 drives T cell proliferation
por: Van Epps, Heather L.
Publicado: (2006)

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population
por: Rodrigues, Fabíola Brasil Barbosa, et al.
Publicado: (2023)

Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling
por: Huang, Teng, et al.
Publicado: (2022)

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
por: Slaats, Jeroen, et al.
Publicado: (2016)

Urinary Excretion of 6-Sulfatoxymelatonin, the Main Metabolite of Melatonin, and Mortality in Stable Outpatient Renal Transplant Recipients
por: van der Veen, Anna, et al.
Publicado: (2020)

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
por: Rose-John, Stefan
Publicado: (2012)

Predictive value of PCT and IL-6 for bacterial infection in children with cancer and febrile neutropenia
por: van der Galiën, Hilde T., et al.
Publicado: (2018)

IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study
por: Sundaresh, Aparna, et al.
Publicado: (2019)

IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
por: Kamińska, Joanna, et al.
Publicado: (2021)

Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R
por: Cupido, Arjen J., et al.
Publicado: (2022)

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6
Publicado: (1996)

Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells
por: Meeren, A. Van Der, et al.
Publicado: (1997)

Pathogenic roles of IL-6 and IL-6 blocking therapy on rheumatoid arthritis
por: Yoshizaki, K, et al.
Publicado: (2003)

Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome
por: Wilson, Lori D, et al.
Publicado: (2012)

An antibody-free LC-MS/MS method for the quantification of intact insulin-like growth factors 1 and 2 in human plasma
por: Pratt, Mark S., et al.
Publicado: (2021)

Peripheral Blood T Cells of Patients with IPAH Have a Reduced Cytokine-Producing Capacity
por: van Uden, Denise, et al.
Publicado: (2022)

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
por: Papadopoulos, Jordan, et al.
Publicado: (2014)

The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention
por: Rana, Brinda K., et al.
Publicado: (2017)

Special issue on Interleukin-6 (IL-6)
por: Rincon, Mercedes
Publicado: (2012)

Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
por: Purohit, A, et al.
Publicado: (2003)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

The nature of human IL-6
por: Puel, Anne, et al.
Publicado: (2019)

IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections.
por: Basso, Beatriz, et al.
Publicado: (2005)

Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon
por: M’Bondoukwé, Noé Patrick, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c8tl61ijh2kmo9eisacci3o1hl