BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule inhibitors and degraders along with RNA interference to ass...

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Detalles Bibliográficos
Autores principales: Weisberg, Ellen, Chowdhury, Basudev, Meng, Chengcheng, Case, Abigail E., Ni, Wei, Garg, Swati, Sattler, Martin, Azab, Abdel Kareem, Sun, Jennifer, Muz, Barbara, Sanchez, Dana, Toure, Anthia, Stone, Richard M., Galinsky, Ilene, Winer, Eric, Gleim, Scott, Gkountela, Sofia, Kedves, Alexia, Harrington, Edmund, Abrams, Tinya, Zoller, Thomas, Vaupel, Andrea, Manley, Paul, Faller, Michael, Chung, BoYee, Chen, Xin, Busenhart, Philipp, Stephan, Christine, Calkins, Keith, Bonenfant, Debora, Thoma, Claudio R., Forrester, William, Griffin, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296512/
https://www.ncbi.nlm.nih.gov/pubmed/35853853
http://dx.doi.org/10.1038/s41408-022-00704-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296512/
https://www.ncbi.nlm.nih.gov/pubmed/35853853
http://dx.doi.org/10.1038/s41408-022-00704-7

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