Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers

Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have comprehensively evaluated Mre11 in epithelial ova...

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Detalles Bibliográficos
Autores principales: Alblihy, Adel, Ali, Reem, Algethami, Mashael, Shoqafi, Ahmed, Toss, Michael S., Brownlie, Juliette, Tatum, Natalie J., Hickson, Ian, Moran, Paloma Ordonez, Grabowska, Anna, Jeyapalan, Jennie N., Mongan, Nigel P., Rakha, Emad A., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296550/
https://www.ncbi.nlm.nih.gov/pubmed/35853939
http://dx.doi.org/10.1038/s41698-022-00298-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296550/
https://www.ncbi.nlm.nih.gov/pubmed/35853939
http://dx.doi.org/10.1038/s41698-022-00298-0

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