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Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy

Progesterone receptor (PGR) is a member of the nuclear receptor superfamily of transcription factors. It is critical for mammary stem cells expansion, mammary ductal branching and alveologenesis. The transcriptional activity of PGR is mainly mediated by activation functions AF1 and AF2. Although the...

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Detalles Bibliográficos
Autores principales: Lee, Shi Hao, Yap, Yeannie H. Y., Lim, Chew Leng, Woo, Amanda Rui En, Lin, Valerie C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296660/
https://www.ncbi.nlm.nih.gov/pubmed/35854046
http://dx.doi.org/10.1038/s41598-022-16289-x