5-Aminolevulinic acid overcomes hypoxia-induced radiation resistance by enhancing mitochondrial reactive oxygen species production in prostate cancer cells

BACKGROUND: The naturally occurring amino acid 5-aminolevulinic acid (5-ALA) is a precursor of protoporphyrin IX (PpIX) biosynthesised in the mitochondria. When accumulated PpIX is excited by light (wavelength of 625–635 nm), reactive oxygen species (ROS) are generated. Here, we investigated whether...

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Detalles Bibliográficos
Autores principales: Owari, Takuya, Tanaka, Nobumichi, Nakai, Yasushi, Miyake, Makito, Anai, Satoshi, Kishi, Shingo, Mori, Shiori, Fujiwara-Tani, Rina, Hojo, Yudai, Mori, Takuya, Kuwada, Masaomi, Fujii, Tomomi, Hasegawa, Masatoshi, Fujimoto, Kiyohide, Kuniyasu, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296661/
https://www.ncbi.nlm.nih.gov/pubmed/35365766
http://dx.doi.org/10.1038/s41416-022-01789-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296661/
https://www.ncbi.nlm.nih.gov/pubmed/35365766
http://dx.doi.org/10.1038/s41416-022-01789-4

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