Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes

Background: Protein aggregates are degraded via the autophagy-lysosome pathway and alterations in the lysosomal system leading to the accumulation of pathogenic proteins, including aggregates of α-synuclein in Parkinson’s disease (PD). The importance of the endolysosomal transient receptor potential...

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Detalles Bibliográficos
Autores principales: Pollmanns, Maike R., Beer, Judith, Rosignol, Ines, Rodriguez-Muela, Natalia, Falkenburger, Björn H., Dinter, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296810/
https://www.ncbi.nlm.nih.gov/pubmed/35875350
http://dx.doi.org/10.3389/fncel.2022.861202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296810/
https://www.ncbi.nlm.nih.gov/pubmed/35875350
http://dx.doi.org/10.3389/fncel.2022.861202

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