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p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1
p73, a p53 family member, undergoes alternative splicing at the 3′ end to produce multiple isoforms, but their expression and activity are largely unknown. Thus, CRISPR was used to knock out exon 12 (E12) in human cancer cell lines and mice, leading to isoform switch from p73α to isoform p73α1. We f...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296871/ https://www.ncbi.nlm.nih.gov/pubmed/35617425 http://dx.doi.org/10.1073/pnas.2123202119 |