The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium

PURPOSE: To explore the effect and mechanism of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasomes on corneal fibrosis. METHODS: The wild-type, NLRP3 knockout (KO), and myeloid cell-specific NLRP3 KO (NLRP3 Lyz-KO) C57 mice were used to establish a corneal scarring model. NLRP3...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Chen, Peng, Luan, Xiaoyu, Yuan, Xinying, Wei, Susu, Li, Yaxin, Guo, Chuanlong, Wu, Xianggen, Di, Guohu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296889/
https://www.ncbi.nlm.nih.gov/pubmed/35838447
http://dx.doi.org/10.1167/iovs.63.8.15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296889/
https://www.ncbi.nlm.nih.gov/pubmed/35838447
http://dx.doi.org/10.1167/iovs.63.8.15

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