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Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non–Small Cell Lung Cancer

PURPOSE: Heat shock protein-90 (HSP90) remains an important cancer target because of its involvement in multiple oncogenic protein pathways and biologic processes. Although many HSP90 inhibitors have been tested in the treatment of KRAS-mutant non–small cell lung cancer (NSCLC), most, including AUY9...

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Detalles Bibliográficos
Autores principales: Yoon, Shinkyo, Yang, Hannah, Ryu, Hyun-Min, Lee, Eunjin, Jo, Yujin, Seo, Seyoung, Kim, Deokhoon, Lee, Chang Hoon, Kim, Wanlim, Jung, Kyung Hae, Park, Sook Ryun, Choi, Eun Kyung, Kim, Sang-We, Park, Kang-Seo, Lee, Dae Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296920/
https://www.ncbi.nlm.nih.gov/pubmed/34607394
http://dx.doi.org/10.4143/crt.2021.651