Hydroarylation of enamides enabled by HFIP via a hexafluoroisopropyl ether as iminium reservoir

Here we describe that HFIP greatly expands the scope with respect to both reaction partners of the Brønsted acid-catalyzed hydroarylation of enamides. The reaction is fast and practical and can be performed on the gram scale. A hexafluoroisopropyl ether intermediate was isolated from the reaction mi...

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Detalles Bibliográficos
Autores principales: Zeidan, Nicolas, Bicic, Sergiu, Mayer, Robert J., Lebœuf, David, Moran, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297520/
https://www.ncbi.nlm.nih.gov/pubmed/35919727
http://dx.doi.org/10.1039/d2sc02012b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297520/
https://www.ncbi.nlm.nih.gov/pubmed/35919727
http://dx.doi.org/10.1039/d2sc02012b

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