Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

Type 1 diabetes is a disorder of immune tolerance that leads to death of insulin-producing islet β cells. We hypothesize that inflammatory signaling within β cells promotes progression of autoimmunity within the islet microenvironment. To test this hypothesis, we deleted the proinflammatory gene enc...

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Detalles Bibliográficos
Autores principales: Piñeros, Annie R., Kulkarni, Abhishek, Gao, Hongyu, Orr, Kara S., Glenn, Lindsey, Huang, Fei, Liu, Yunlong, Gannon, Maureen, Syed, Farooq, Wu, Wenting, Anderson, Cara M., Evans-Molina, Carmella, McDuffie, Marcia, Nadler, Jerry L., Morris, Margaret A., Mirmira, Raghavendra G., Tersey, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297711/
https://www.ncbi.nlm.nih.gov/pubmed/35767947
http://dx.doi.org/10.1016/j.celrep.2022.111011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297711/
https://www.ncbi.nlm.nih.gov/pubmed/35767947
http://dx.doi.org/10.1016/j.celrep.2022.111011

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