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Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

Type 1 diabetes is a disorder of immune tolerance that leads to death of insulin-producing islet β cells. We hypothesize that inflammatory signaling within β cells promotes progression of autoimmunity within the islet microenvironment. To test this hypothesis, we deleted the proinflammatory gene enc...

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Detalles Bibliográficos
Autores principales:	Piñeros, Annie R., Kulkarni, Abhishek, Gao, Hongyu, Orr, Kara S., Glenn, Lindsey, Huang, Fei, Liu, Yunlong, Gannon, Maureen, Syed, Farooq, Wu, Wenting, Anderson, Cara M., Evans-Molina, Carmella, McDuffie, Marcia, Nadler, Jerry L., Morris, Margaret A., Mirmira, Raghavendra G., Tersey, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297711/ https://www.ncbi.nlm.nih.gov/pubmed/35767947 http://dx.doi.org/10.1016/j.celrep.2022.111011

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