Inverting the Stereoselectivity of an NADH‐Dependent Imine‐Reductase Variant

Imine reductases (IREDs) offer biocatalytic routes to chiral amines and have a natural preference for the NADPH cofactor. In previous work, we reported enzyme engineering of the (R)‐selective IRED from Myxococcus stipitatus (NADH‐IRED‐Ms) yielding a NADH‐dependent variant with high catalytic efficie...

Descripción completa

Detalles Bibliográficos
Autores principales: Stockinger, Peter, Borlinghaus, Niels, Sharma, Mahima, Aberle, Benjamin, Grogan, Gideon, Pleiss, Jürgen, Nestl, Bettina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297850/
https://www.ncbi.nlm.nih.gov/pubmed/35873105
http://dx.doi.org/10.1002/cctc.202101057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297850/
https://www.ncbi.nlm.nih.gov/pubmed/35873105
http://dx.doi.org/10.1002/cctc.202101057

Ejemplares similares