Cargando…

Coupling Interrupted Fischer and Multicomponent Joullié‐Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics

The generation of peptidomimetic substructures for medicinal chemistry purposes requires effective and divergent synthetic methods. We present in this work an efficient flow process that allows quick modulation of reagents for Joullié‐Ugi multicomponent reaction, using spiroindolenines as core motif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfano, Antonella Ilenia, Buommino, Elisabetta, Ferraro, Maria Grazia, Irace, Carlo, Zampella, Angela, Lange, Heiko, Brindisi, Margherita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297956/ https://www.ncbi.nlm.nih.gov/pubmed/34585536 http://dx.doi.org/10.1002/cmdc.202100474

Ejemplares similares

Stereodivergent access to all four stereoisomers of chiral tetrahydrobenzo[f][1,4]oxazepines, through highly diastereoselective multicomponent Ugi–Joullié reaction
por: Pinna, Alessandro, et al.
Publicado: (2020)

Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions
por: Barreto, Angélica de Fátima S, et al.
Publicado: (2016)

Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics
por: Vishwanatha, Thimmalapura M., et al.
Publicado: (2017)

Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
por: Barone, Simona, et al.
Publicado: (2022)

The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction
por: Madej, Arleta, et al.
Publicado: (2018)

From Ugi Multicomponent Reaction to Linkers for Bioconjugation
por: Ramos-Tomillero, Iván, et al.
Publicado: (2020)

Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution
por: Alfano, Antonella Ilenia, et al.
Publicado: (2022)

Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
por: Abdelraheem, Eman M. M., et al.
Publicado: (2017)

Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation
por: Pelliccia, Sveva, et al.
Publicado: (2023)

TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics
por: Kunig, Verena B. K., et al.
Publicado: (2020)

Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions
por: Kolomiiets, Oleksandr V, et al.
Publicado: (2023)

Review on the Ugi Multicomponent Reaction Mechanism and the Use of Fluorescent Derivatives as Functional Chromophores
por: Rocha, Rafael O., et al.
Publicado: (2020)

Removal of copper ions by functionalized biochar based on a multicomponent Ugi reaction
por: Liu, Qi, et al.
Publicado: (2021)

Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
por: Koopmanschap, Gijs, et al.
Publicado: (2014)

Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization
por: Moni, Lisa, et al.
Publicado: (2014)

Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions †
por: Sultani, Haider N., et al.
Publicado: (2021)

A methanol and protic ionic liquid Ugi multicomponent reaction path to cytotoxic α-phenylacetamido amides
por: Al Otaibi, Ahmed, et al.
Publicado: (2019)

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction
por: Ji, Xiangkai, et al.
Publicado: (2022)

Combining the Ugi-azide multicomponent reaction and rhodium(III)-catalyzed annulation for the synthesis of tetrazole-isoquinolone/pyridone hybrids
por: Ojeda, Gerardo M, et al.
Publicado: (2019)

Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing
por: Aronow, Jonas, et al.
Publicado: (2018)

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts
por: Zidan, Alaa, et al.
Publicado: (2019)

Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Müller Reactions
por: Wang, Yuanze, et al.
Publicado: (2019)

Structure-Acid Lability Relationship of N-alkylated α,α-dialkylglycine Obtained via a Ugi Multicomponent Reaction
por: Ramos-Tomillero, Iván, et al.
Publicado: (2021)

Enantioselective Ugi and Ugi-azide reactions catalyzed by anionic stereogenic-at-cobalt(III) complexes
por: Sun, Bing-Bing, et al.
Publicado: (2022)

Total Syntheses of Dihydroindole Aspidosperma Alkaloids: Reductive Interrupted Fischer Indolization Followed by Redox Diversification
por: Martin, Gábor, et al.
Publicado: (2020)

To chase or not to chase: A study on the role of mentalization and alcohol consumption in chasing behavior
por: Nigro, Giovanna, et al.
Publicado: (2019)

Antioxidant Activity of Bioactive Peptide Fractions from Germinated Soybeans Conjugated to Fe(3)O(4) Nanoparticles by the Ugi Multicomponent Reaction
por: Augusto-Jimenez, Yarelys Elena, et al.
Publicado: (2021)

Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
por: Alfano, Antonella Ilenia, et al.
Publicado: (2023)

Peptidomimetics II
por: Lubell, William D
Publicado: (2016)

Chasing Carbon
Publicado: (2020)

Unimolecular Exciplexes by Ugi Four-Component Reaction
por: Ochs, Maria, et al.
Publicado: (2019)

Keto-Enol Tautomerism in Passerini and Ugi Adducts
por: Pertejo, Pablo, et al.
Publicado: (2021)

Highly Stereoselective Ugi/Pictet–Spengler Sequence
por: Zhang, Bidong, et al.
Publicado: (2022)

Structure and Conformation of Novel BODIPY Ugi Adducts
por: Arroyo‐Córdoba, Ismael Javier, et al.
Publicado: (2022)

Photoredox-catalyzed multicomponent Petasis reaction in batch and continuous flow with alkyl boronic acids
por: Oliva, Monica, et al.
Publicado: (2021)

Peptidomimetics in cancer targeting
por: Gomari, Mohammad Mahmoudi, et al.
Publicado: (2022)

Dr. L. C. Fischer, Atlanta Surgical Clinic, at the Davis & Fischer Sanatorium
Publicado: (1913)

Pursuit tracks chase: exploring the role of eye movements in the detection of chasing
por: Šimkovic, Matúš, et al.
Publicado: (2015)

Application of heterocyclic aldehydes as components in Ugi–Smiles couplings
por: Mason, Katelynn M, et al.
Publicado: (2016)

Two-Step Macrocycle Synthesis by Classical Ugi Reaction
por: Abdelraheem, Eman M. M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3j1375na4akfepn6bv9hstot8u