Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling

Moxifloxacin has an important role in the treatment of tuberculosis (TB). Unfortunately, coadministration with the cornerstone TB drug rifampicin results in suboptimal plasma exposure. We aimed to gain insight into the moxifloxacin pharmacokinetics and the interaction with rifampicin. Moreover, we p...

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Detalles Bibliográficos
Autores principales: Litjens, Carlijn H. C., Verscheijden, Laurens F. M., Bolwerk, Celine, Greupink, Rick, Koenderink, Jan B., van den Broek, Petra H. H., van den Heuvel, Jeroen J. M. W., Svensson, Elin M., Boeree, Martin J., Magis‐Escurra, Cecile, Hoefsloot, Wouter, van Crevel, Reinout, van Laarhoven, Arjan, van Ingen, Jakko, Kuipers, Saskia, Ruslami, Rovina, Burger, David M., Russel, Frans G. M., Aarnoutse, Rob E., te Brake, Lindsey H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Physiologically Based Pharmacokinetic Modeling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297990/
https://www.ncbi.nlm.nih.gov/pubmed/34554580
http://dx.doi.org/10.1002/jcph.1972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297990/
https://www.ncbi.nlm.nih.gov/pubmed/34554580
http://dx.doi.org/10.1002/jcph.1972

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