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Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling
Moxifloxacin has an important role in the treatment of tuberculosis (TB). Unfortunately, coadministration with the cornerstone TB drug rifampicin results in suboptimal plasma exposure. We aimed to gain insight into the moxifloxacin pharmacokinetics and the interaction with rifampicin. Moreover, we p...
Autores principales: | Litjens, Carlijn H. C., Verscheijden, Laurens F. M., Bolwerk, Celine, Greupink, Rick, Koenderink, Jan B., van den Broek, Petra H. H., van den Heuvel, Jeroen J. M. W., Svensson, Elin M., Boeree, Martin J., Magis‐Escurra, Cecile, Hoefsloot, Wouter, van Crevel, Reinout, van Laarhoven, Arjan, van Ingen, Jakko, Kuipers, Saskia, Ruslami, Rovina, Burger, David M., Russel, Frans G. M., Aarnoutse, Rob E., te Brake, Lindsey H. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297990/ https://www.ncbi.nlm.nih.gov/pubmed/34554580 http://dx.doi.org/10.1002/jcph.1972 |
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