Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor–Positive Allosteric Modulator, in Patients With Parkinson Disease

Mevidalen (LY3154207) is a positive allosteric modulator of the dopamine D1 receptor that enhances the affinity of dopamine for the D1 receptor. The safety, tolerability, motor effects, and pharmacokinetics of mevidalen were studied in patients with Parkinson disease. Mevidalen or placebo was given...

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Detalles Bibliográficos
Autores principales: Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Pugh, Melissa, Ardayfio, Paul, Kielbasa, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298003/
https://www.ncbi.nlm.nih.gov/pubmed/34664427
http://dx.doi.org/10.1002/cpdd.1039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298003/
https://www.ncbi.nlm.nih.gov/pubmed/34664427
http://dx.doi.org/10.1002/cpdd.1039

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