Cargando…

Control of hippocampal prothrombin kringle‐2 (pKr‐2) expression reduces neurotoxic symptoms in five familial Alzheimer's disease mice

BACKGROUND AND PURPOSE: There is a scarcity of information regarding the role of prothrombin kringle‐2 (pKr‐2), which can be generated by active thrombin, in hippocampal neurodegeneration and Alzheimer's disease (AD). EXPERIMENTAL APPROACH: To assess the role of pKr‐2 in association with the ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sehwan, Moon, Gyeong Joon, Kim, Hyung Jun, Kim, Do‐Geun, Kim, Jaekwang, Nam, Youngpyo, Sharma, Chanchal, Leem, Eunju, Lee, Shinrye, Kim, Kyu‐Sung, Ha, Chang Man, McLean, Catriona, Jin, Byung Kwan, Shin, Won‐Ho, Kim, Dong Woon, Oh, Yong‐Seok, Hong, Chang‐Won, Kim, Sang Ryong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298060/ https://www.ncbi.nlm.nih.gov/pubmed/34524687 http://dx.doi.org/10.1111/bph.15681

Ejemplares similares

pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain
por: Kim, Sehwan, et al.
Publicado: (2023)

Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System
por: Leem, Eunju, et al.
Publicado: (2016)

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease
por: Shin, Won-Ho, et al.
Publicado: (2015)

Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis
por: Lee, Jae Man, et al.
Publicado: (2022)

Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease
por: Sharma, Chanchal, et al.
Publicado: (2021)

Interleukin-13 Propagates Prothrombin Kringle-2-Induced Neurotoxicity in Hippocampi In Vivo via Oxidative Stress
por: Jeong, Jae Yeong, et al.
Publicado: (2021)

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish
por: Grzegorski, Steven J., et al.
Publicado: (2020)

Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress
por: Jeong, Jae Yeong, et al.
Publicado: (2019)

Mesenchymal Stem Cell Transplantation Ameliorates Ara-C-Induced Motor Deficits in a Mouse Model of Cerebellar Ataxia
por: Park, Narae, et al.
Publicado: (2023)

Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo
por: Kim, Sehwan, et al.
Publicado: (2018)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
por: Lee, Shinrye, et al.
Publicado: (2020)

Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo
por: Kim, Sehwan, et al.
Publicado: (2017)

Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases
por: Nam, Youngpyo, et al.
Publicado: (2021)

Pathophysiological Role of Microglial Activation Induced by Blood-Borne Proteins in Alzheimer’s Disease
por: Kim, Sehwan, et al.
Publicado: (2023)

Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson's disease
por: Leem, Eunju, et al.
Publicado: (2020)

Interleukin-4-Mediated Oxidative Stress Is Harmful to Hippocampal Neurons of Prothrombin Kringle-2-Lesioned Rat In Vivo
por: Chung, Young Cheul, et al.
Publicado: (2020)

Neurotrophic interactions between neurons and astrocytes following AAV1‐Rheb(S16H) transduction in the hippocampus in vivo
por: Jeon, Min‐Tae, et al.
Publicado: (2019)

Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
por: Lee, Shinrye, et al.
Publicado: (2021)

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
por: Bok, Eugene, et al.
Publicado: (2019)

Naringin: A Protector of the Nigrostriatal Dopaminergic Projection
por: Jung, Un Ju, et al.
Publicado: (2014)

Role of the kringle‐like domain in glycoprotein NMB for its tumorigenic potential
por: Xie, Rudy, et al.
Publicado: (2019)

Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids
por: Kim, Tae Yeon, et al.
Publicado: (2020)

Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo
por: Yun, Dongyoung, et al.
Publicado: (2020)

Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo
por: Leem, Eunju, et al.
Publicado: (2018)

Suppression of Colorectal Cancer Liver Metastasis by Apolipoprotein(a) Kringle V in a Nude Mouse Model through the Induction of Apoptosis in Tumor-Associated Endothelial Cells
por: Ahn, Jin-Hyung, et al.
Publicado: (2014)

Human Apolipoprotein(a) Kringle V Inhibits Ischemia-Induced Retinal Neovascularization via Suppression of Fibronectin-Mediated Angiogenesis
por: Lim, Yangmi, et al.
Publicado: (2012)

Role of the Lipid Membrane and Membrane Proteins in Tau Pathology
por: Bok, Eugene, et al.
Publicado: (2021)

Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model
por: Lee, Ji Min, et al.
Publicado: (2018)

Miguel Llinás and the Structure of the Kringle Fold
por: Patthy, Laszlo
Publicado: (2021)

Role of thromboelastography in the evaluation of septic shock patients with normal prothrombin time and activated partial thromboplastin time
por: Kim, Sang-Min, et al.
Publicado: (2021)

Antiangiogenic Therapy with Human Apolipoprotein(a) Kringle V and Paclitaxel in a Human Ovarian Cancer Mouse Model()()
por: Yu, Hyun-Kyung, et al.
Publicado: (2014)

Therapeutic monitoring of rivaroxaban in dogs using thromboelastography and prothrombin time
por: Bae, Junwoo, et al.
Publicado: (2019)

Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation
por: Nam, Youngpyo, et al.
Publicado: (2020)

Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide
por: Choi, Mal-Gi, et al.
Publicado: (2018)

Selective separation of Xe/Kr and adsorption of water in a microporous hydrogen-bonded organic framework
por: Lee, Wang-Geun, et al.
Publicado: (2019)

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease
por: Sharma, Chanchal, et al.
Publicado: (2021)

Oxidative stress: culprit or consequence in Alzheimer’s amyloidopathy
por: Sharma, Chanchal, et al.
Publicado: (2023)

PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
por: Kim, Yoosik, et al.
Publicado: (2014)

Shape dynamics in neutron-rich Kr isotopes: Coulomb excitation of $^{92}Kr$, $^{94}Kr$ and $^{96}Kr$
por: Albers, M, et al.
Publicado: (2013)

Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer’s Disease
por: Moon, Gyeong Joon, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lk94ghl3stk46sm0u2k8m2oru7