Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods
The Human Epidemiology and Response to SARS-CoV-2 (HEROS) is a prospective multi-city 6-month incidence study which was conducted from May 2020-February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and al...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298141/ https://www.ncbi.nlm.nih.gov/pubmed/35860216 http://dx.doi.org/10.1101/2022.07.09.22277457 |
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author | Fulkerson, Patricia C. Lussier, Stephanie J. Bendixsen, Casper G. Castina, Sharon M. Gebretsadik, Tebeb Marlin, Jessica S. Russell, Patty B. Seibold, Max A. Everman, Jamie L. Moore, Camille M. Snyder, Brittney M. Thompson, Kathy Tregoning, George S. Wellford, Stephanie Arbes, Samuel J. Bacharier, Leonard B. Calatroni, Agustin Camargo, Carlos A. Dupont, William D. Furuta, Glenn T. Gruchalla, Rebecca S. Gupta, Ruchi S. Hershey, Gurjit Khurana Jackson, Daniel J. Johnson, Christine C. Kattan, Meyer Liu, Andrew H. Murrison, Liza O’Connor, George T. Phipatanakul, Wanda Rivera-Spoljaric, Katherine Rothenberg, Marc E. Seroogy, Christine M. Teach, Stephen J. Zoratti, Edward M. Togias, Alkis Hartert, Tina V. |
author_facet | Fulkerson, Patricia C. Lussier, Stephanie J. Bendixsen, Casper G. Castina, Sharon M. Gebretsadik, Tebeb Marlin, Jessica S. Russell, Patty B. Seibold, Max A. Everman, Jamie L. Moore, Camille M. Snyder, Brittney M. Thompson, Kathy Tregoning, George S. Wellford, Stephanie Arbes, Samuel J. Bacharier, Leonard B. Calatroni, Agustin Camargo, Carlos A. Dupont, William D. Furuta, Glenn T. Gruchalla, Rebecca S. Gupta, Ruchi S. Hershey, Gurjit Khurana Jackson, Daniel J. Johnson, Christine C. Kattan, Meyer Liu, Andrew H. Murrison, Liza O’Connor, George T. Phipatanakul, Wanda Rivera-Spoljaric, Katherine Rothenberg, Marc E. Seroogy, Christine M. Teach, Stephen J. Zoratti, Edward M. Togias, Alkis Hartert, Tina V. |
author_sort | Fulkerson, Patricia C. |
collection | PubMed |
description | The Human Epidemiology and Response to SARS-CoV-2 (HEROS) is a prospective multi-city 6-month incidence study which was conducted from May 2020-February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other NIH-funded pediatric research studies and their household members. Households participated in weekly surveys and biweekly nasal sampling regardless of symptoms. The aim of this report is to widely share the methods and study instruments and to describe the rationale, design, execution, logistics and characteristics of a large, observational, household-based, remote cohort study of SARS-CoV-2 infection and transmission in households with children. The study enrolled a total of 5,598 individuals, including 1,913 principal participants (children), 1,913 primary caregivers, 729 secondary caregivers and 1,043 other household children. This study was successfully implemented without necessitating any in-person research visits and provides an approach for rapid execution of clinical research. |
format | Online Article Text |
id | pubmed-9298141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-92981412022-07-21 Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods Fulkerson, Patricia C. Lussier, Stephanie J. Bendixsen, Casper G. Castina, Sharon M. Gebretsadik, Tebeb Marlin, Jessica S. Russell, Patty B. Seibold, Max A. Everman, Jamie L. Moore, Camille M. Snyder, Brittney M. Thompson, Kathy Tregoning, George S. Wellford, Stephanie Arbes, Samuel J. Bacharier, Leonard B. Calatroni, Agustin Camargo, Carlos A. Dupont, William D. Furuta, Glenn T. Gruchalla, Rebecca S. Gupta, Ruchi S. Hershey, Gurjit Khurana Jackson, Daniel J. Johnson, Christine C. Kattan, Meyer Liu, Andrew H. Murrison, Liza O’Connor, George T. Phipatanakul, Wanda Rivera-Spoljaric, Katherine Rothenberg, Marc E. Seroogy, Christine M. Teach, Stephen J. Zoratti, Edward M. Togias, Alkis Hartert, Tina V. medRxiv Article The Human Epidemiology and Response to SARS-CoV-2 (HEROS) is a prospective multi-city 6-month incidence study which was conducted from May 2020-February 2021. The objectives were to identify risk factors for SARS-CoV-2 infection and household transmission among children and people with asthma and allergic diseases, and to use the host nasal transcriptome sampled longitudinally to understand infection risk and sequelae at the molecular level. To overcome challenges of clinical study implementation due to the coronavirus pandemic, this surveillance study used direct-to-participant methods to remotely enroll and prospectively follow eligible children who are participants in other NIH-funded pediatric research studies and their household members. Households participated in weekly surveys and biweekly nasal sampling regardless of symptoms. The aim of this report is to widely share the methods and study instruments and to describe the rationale, design, execution, logistics and characteristics of a large, observational, household-based, remote cohort study of SARS-CoV-2 infection and transmission in households with children. The study enrolled a total of 5,598 individuals, including 1,913 principal participants (children), 1,913 primary caregivers, 729 secondary caregivers and 1,043 other household children. This study was successfully implemented without necessitating any in-person research visits and provides an approach for rapid execution of clinical research. Cold Spring Harbor Laboratory 2022-07-10 /pmc/articles/PMC9298141/ /pubmed/35860216 http://dx.doi.org/10.1101/2022.07.09.22277457 Text en https://creativecommons.org/publicdomain/zero/1.0/This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license (https://creativecommons.org/publicdomain/zero/1.0/) . |
spellingShingle | Article Fulkerson, Patricia C. Lussier, Stephanie J. Bendixsen, Casper G. Castina, Sharon M. Gebretsadik, Tebeb Marlin, Jessica S. Russell, Patty B. Seibold, Max A. Everman, Jamie L. Moore, Camille M. Snyder, Brittney M. Thompson, Kathy Tregoning, George S. Wellford, Stephanie Arbes, Samuel J. Bacharier, Leonard B. Calatroni, Agustin Camargo, Carlos A. Dupont, William D. Furuta, Glenn T. Gruchalla, Rebecca S. Gupta, Ruchi S. Hershey, Gurjit Khurana Jackson, Daniel J. Johnson, Christine C. Kattan, Meyer Liu, Andrew H. Murrison, Liza O’Connor, George T. Phipatanakul, Wanda Rivera-Spoljaric, Katherine Rothenberg, Marc E. Seroogy, Christine M. Teach, Stephen J. Zoratti, Edward M. Togias, Alkis Hartert, Tina V. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title | Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title_full | Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title_fullStr | Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title_full_unstemmed | Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title_short | Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods |
title_sort | human epidemiology and response to sars-cov-2 (heros): objectives, design and enrollment results of a 12-city remote observational surveillance study of households with children using direct-to-participant methods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298141/ https://www.ncbi.nlm.nih.gov/pubmed/35860216 http://dx.doi.org/10.1101/2022.07.09.22277457 |
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