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Controlling Enzymatic Activity by Modulating the Oligomerization State via Chemical Rescue and Optical Control

Selective switching of enzymatic activity has been a longstanding goal in synthetic biology. Drastic changes in activity upon mutational manipulation of the oligomerization state of enzymes have frequently been reported in the literature, but scarcely exploited for switching. Using geranylgeranylgly...

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Detalles Bibliográficos
Autores principales: Kropp, Cosimo, Bruckmann, Astrid, Babinger, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298306/
https://www.ncbi.nlm.nih.gov/pubmed/34633135
http://dx.doi.org/10.1002/cbic.202100490