Inhibition of hypoxia‐induced Mucin 1 alters the proteomic composition of human osteoblast‐produced extracellular matrix, leading to reduced osteogenic and angiogenic potential

The bone microenvironment is one of the most hypoxic regions of the human body and in experimental models; hypoxia inhibits osteogenic differentiation of mesenchymal stromal cells (MSCs). Our previous work revealed that Mucin 1 (MUC1) was dynamically expressed during osteogenic differentiation of hu...

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Detalles Bibliográficos
Autores principales: Jadaun, Pavitra K., Zhang, Shuang, Koedam, Marijke, Demmers, Jeroen, Chatterjee, Suvro, van Leeuwen, Johannes P., van der Eerden, Bram C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298310/
https://www.ncbi.nlm.nih.gov/pubmed/34687046
http://dx.doi.org/10.1002/jcp.30617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298310/
https://www.ncbi.nlm.nih.gov/pubmed/34687046
http://dx.doi.org/10.1002/jcp.30617

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