Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4‐methylaminoantipyrine

AIMS: Metamizole (dipyrone) is a prodrug not detectable in serum or urine after oral ingestion. The primary metabolite, 4‐methylaminoantipyrine (4‐MAA), can be N‐demethylated to 4‐aminoantipyrine (4‐AA) or oxidized to 4‐formylaminoantipyrine (4‐FAA) by cytochrome P450 (CYP)‐dependent reactions. We a...

Descripción completa

Detalles Bibliográficos
Autores principales: Bachmann, Fabio, Meyer zu Schwabedissen, Henriette E., Duthaler, Urs, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298350/
https://www.ncbi.nlm.nih.gov/pubmed/34648192
http://dx.doi.org/10.1111/bcp.15108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298350/
https://www.ncbi.nlm.nih.gov/pubmed/34648192
http://dx.doi.org/10.1111/bcp.15108

Ejemplares similares