Cargando…

Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy

The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, these complementary pathways keep the intracellular environment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giovannucci, Tatiana A., Salomons, Florian A., Stoy, Henriette, Herzog, Laura K., Xu, Shanshan, Qian, Weixing, Merino, Lara G., Gierisch, Maria E., Haraldsson, Martin, Lystad, Alf H., Uvell, Hanna, Simonsen, Anne, Gustavsson, Anna-Lena, Vallin, Michaela, Dantuma, Nico P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298443/ https://www.ncbi.nlm.nih.gov/pubmed/34740308 http://dx.doi.org/10.1080/15548627.2021.1988359

Ejemplares similares

Reporter-Based Screens for the Ubiquitin/Proteasome System
por: Gierisch, Maria E., et al.
Publicado: (2020)

Cytosolic stress granules relieve the ubiquitin‐proteasome system in the nuclear compartment
por: Xu, Shanshan, et al.
Publicado: (2022)

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
por: Giovannucci, Tatiana A., et al.
Publicado: (2021)

The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy
por: Herzog, Laura K., et al.
Publicado: (2019)

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling
por: Dantuma, Nico P., et al.
Publicado: (2006)

Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
por: Dantuma, Nico P., et al.
Publicado: (2016)

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
por: Dantuma, Nico P., et al.
Publicado: (2014)

Ubiquitin crosstalk connecting cellular processes
por: Groothuis, Tom AM, et al.
Publicado: (2006)

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
por: Lindsten, Kristina, et al.
Publicado: (2002)

Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery
por: Lystad, Alf Håkon, et al.
Publicado: (2019)

A spider silk-derived solubility domain inhibits nuclear and cytosolic protein aggregation in human cells
por: Schellhaus, Anna Katharina, et al.
Publicado: (2022)

The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex
por: Bott, Laura C., et al.
Publicado: (2016)

Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4
por: Pfeiffer, Annika, et al.
Publicado: (2017)

Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks
por: Dantuma, Nico P., et al.
Publicado: (2016)

Autophagosome biogenesis: From membrane growth to closure
por: Melia, Thomas J., et al.
Publicado: (2020)

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
por: Heinen, Christian, et al.
Publicado: (2011)

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation
por: Gödderz, Daniela, et al.
Publicado: (2015)

K63-linked ubiquitylation induces global sequestration of mitochondria
por: Richard, Thibaud J. C., et al.
Publicado: (2020)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Stress granules: friend or foe in neurodegenerative disorders?
por: Xu, Shanshan, et al.
Publicado: (2023)

Poxvirus Exploitation of the Ubiquitin-Proteasome System
por: Barry, Michele, et al.
Publicado: (2010)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
por: Ernst, Robert, et al.
Publicado: (2011)

The ubiquitin-proteasome system in Alzheimer's disease
por: Oddo, Salvatore
Publicado: (2008)

Autoregulation of the 26S proteasome by in situ ubiquitination
por: Jacobson, Andrew D., et al.
Publicado: (2014)

Ubiquitin Proteasome System in Stress and Disease
por: Karpov, Dmitry, et al.
Publicado: (2012)

Intracellular Dynamics of the Ubiquitin-Proteasome-System
por: Chowdhury, Maisha, et al.
Publicado: (2015)

Ubiquitin-Proteasome System in Neurodegenerative Disorders
por: Rao, Geeta, et al.
Publicado: (2015)

The Ubiquitin–Proteasome System in Immune Cells
por: Çetin, Gonca, et al.
Publicado: (2021)

Ubiquitin-proteasome system in diabetic retinopathy
por: Svikle, Zane, et al.
Publicado: (2022)

Copper homeostasis and the ubiquitin proteasome system
por: Zhang, Bichao, et al.
Publicado: (2023)

The Ubiquitin–Proteasome System in Tumor Metabolism
por: Wang, Jie, et al.
Publicado: (2023)

The price of longevity
por: Dantuma, Nico P., et al.
Publicado: (2020)

The role of the ubiquitination-proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer
por: Orlowski, Robert Z, et al.
Publicado: (2003)

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems
por: Amelio, Ivano, et al.
Publicado: (2015)

Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants
por: Su, Tong, et al.
Publicado: (2020)

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
por: Bedford, Lynn, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_s41na65umd9g2qj0urjts56fc9