Strong and Specific Recognition of CAG/CTG Repeat DNA (5’‐dWGCWGCW‐3’) by a Cyclic Pyrrole‐Imidazole Polyamide

Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole‐imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequence. The double‐stranded DNA melting temperatur...

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Detalles Bibliográficos
Autores principales: Hirose, Yuki, Ohno, Tomo, Asamitsu, Sefan, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298716/
https://www.ncbi.nlm.nih.gov/pubmed/34796607
http://dx.doi.org/10.1002/cbic.202100533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298716/
https://www.ncbi.nlm.nih.gov/pubmed/34796607
http://dx.doi.org/10.1002/cbic.202100533

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